Neuropsychological outcomes at midlife following moderate to severe malnutrition in infancy

Citation:

Waber DP, Bryce CP, Fitzmaurice GM, Zichlin ML, McGaughy J, Girard JM, Galler JR. Neuropsychological outcomes at midlife following moderate to severe malnutrition in infancy. Neuropsychology. 2014;28 :530-40.

Date Published:

Jul

Abstract:

OBJECTIVE: To compare neuropsychological profiles of adults who had experienced an episode of moderate to severe protein-energy malnutrition confined to the first year of life with that of a healthy community comparison group. METHOD: We assessed neuropsychological functioning in a cohort of Barbadian adults, all of whom had birth weight >2268 g. The previously malnourished group (N = 77, mean age = 38 years, 53% male) had been hospitalized during the first year of life for moderate to severe protein energy malnutrition and subsequently enrolled in a program providing nutrition education, home visits and subsidized foods to 12 years of age. They also had documented, adequate nutrition throughout childhood and complete catch-up in growth by the end of adolescence. The healthy comparison group (N = 59, mean age = 38 years, 54% male) were recruited as children from the same classrooms and neighborhoods. RESULTS: Adjusted for effects of standard of living during childhood and adolescence and current intellectual ability level, there were nutrition group differences on measures of cognitive flexibility and concept formation, as well as initiation, verbal fluency, working memory, processing speed, and visuospatial integration. Behavioral and cognitive regulation were not affected. CONCLUSIONS: Postnatal malnutrition confined to the first year of life is associated with neurocognitive compromise persisting into midlife. Early malnutrition may have a specific neuropsychological signature, affecting response initiation to a somewhat greater extent than response inhibition.

Notes:

1931-1559Waber, Deborah PBryce, Cyralene PFitzmaurice, Garrett MZichlin, Miriam LMcGaughy, JillGirard, Jonathan MGaller, Janina RR01 HD060986/HD/NICHD NIH HHS/United StatesP30 HD018655/HD/NICHD NIH HHS/United StatesR01 MH074811/MH/NIMH NIH HHS/United StatesP30 HD18655/HD/NICHD NIH HHS/United StatesR01 MH065877/MH/NIMH NIH HHS/United StatesJournal ArticleResearch Support, N.I.H., ExtramuralNeuropsychology. 2014 Jul;28(4):530-40. doi: 10.1037/neu0000058. Epub 2014 Mar 17.